The present invention is directed to a reconstituted pulmonary surfactant comprising a lipid carrier, a combination of polypeptide analog of the native surfactant protein SP-C with a particular polypeptide analog of the native surfactant protein SP-B. The invention is also directed to the pharmaceutical formulations thereof and to its use for the treatment or prophylaxis of RDS and other respiratory disorders.Predmetni pronalazak se odnosi na rekonstituisani pulmonalni surfaktant koji sadrži lipidni nosač, kombinaciju analoga polipeptida nativnog surfaktanta proteina SP-C sa određenim analogom polipeptida nativnog surfaktanta proteina SP-B. Pronalazak se takođe odnosi na farmaceutske formulacije od njih i na njihovu upotrebu za lečenje ili profilaksu RDS i drugih respiratornih poremećaja.