Brookhaven Sciences Associates, LLC;University of Rochester;Research Foundation of the State University of New York
发明人:
Benjamin J. Luft,John J. Dunn,Shohei Koide,Catherine L. Lawson
申请号：
US13944078
公开号：
US08992936B2
申请日:
2013.07.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
