The present invention provides compounds of formula (I);or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.本發明提供式(I)化合物,或其醫藥學上可接受之鹽,其中變數係如本文中所定義。本發明提供一種製造式(I)化合物之方法、其治療用途、與其他藥理活性劑之組合,及醫藥組合物。