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S1p receptor modulator modified release formulations
专利权人:
NOVARTIS AG
发明人:
BOUILLOT PHILIPPE,REYNAUD EMERIC
申请号:
NZ61242012
公开号:
NZ612420A
申请日:
2012.01.05
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
Disclosed is a solid phase pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and siponimod (BAF312 / 1-{ 4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl} -azetidine-3-carboxylic acid) or a pharmacologically acceptable salt (particularly the hemifumarate salt), solvate or hydrate thereof, wherein siponimod is in a mixture of materials which is free of basic compounds, with the exclusion of basic forms of siponimod itself. Also disclosed is a solid phase pharmaceutical composition such as a tablet comprising one or more pharmaceutically acceptable excipients and siponimod , wherein siponimod has a crystallinity of 80% or more and wherein the siponimod is in a mixture of materials which is free of basic compounds, with the exclusion of basic forms of siponimod itself.
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