CHARIFSON, PAUL S.,查瑞弗森 保罗 S,查瑞弗森 保羅 S,H COME, JON H.,柯米 裘,柯米 裘,COURT, JOHN J.,寇特 约翰 J,寇特 約翰 J,GALE-DAY, ZACHARY,盖尔戴 萨克力,蓋爾戴 薩克力,GU, WENXIN,顾 文鑫,顧 文鑫,JACKSON, KATRINA L.,杰克森 卡崔娜 L,傑克森 卡崔娜 L,MAGAVI, SA
申请号：
TW106143290
公开号：
TW201833087A
申请日:
2017.12.08
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
Disclosed are chemical entities which are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Formula (I) has the structure,, wherein: R1a, R1b, R2, R3, R4a, R4band Y are as defined herein. These chemical entities are useful for reduction of very long chain fatty acid levels. These chemical entities and pharmaceutically acceptable compositions comprising such chemical entities can be useful for treating various diseases, disorders and conditions, such as adrenoleukodystrophy (ALD).本發明揭示化學個體,即式(I)化合物及其醫藥學上可接受之鹽,其中式(I)具有以下結構,其中: R1a、R1b、R2、R3、R4a、R4b及Y係如本文所定義。該等化學個體可用於降低非常長鏈脂肪酸含量。該等化學個體及包含該等化學個體的醫藥學上可接受之組合物可以用於治療各種疾病、病症及病狀,諸如腎上腺腦白質營養不良(ALD)。
