PROBLEM TO BE SOLVED: To provide a technology to defeat the function of specific organ/tissue of an animal.SOLUTION: According to the present invention, there is provided a gene comprising DNA of the following (a), (b), or (c): (a) DNA containing a specific base sequence； (b) a DNA that hybridizes with a specific base sequence under stringent conditions and encodes a protein having an ADP-ribosylation activity of a guanine residue of a nucleic acid； (c) and a complementary strand of the DNA of (a) or (b). Here, the polypeptide has a specific amino acid sequence or has an amino acid sequence in which a part of the sequence is substituted, added, or deleted or an amino acid sequence having 85% or more identity with the amino acid of the sequence, the polypeptide having the ADP-liposylation activity on a guanine residue in nucleic acids.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2018,JPO&INPIT【課題】動物の特定の臓器／組織の機能を不全化する技術の提供。【解決手段】以下の（ａ）、（ｂ）又は（ｃ）のＤＮＡを含む遺伝子。（ａ）特定の塩基配列を含むＤＮＡ（ｂ）特定の塩基配列とストリンジェントな条件下でハイブリダイズし、核酸のグアニン残基のＡＤＰリボシル化活性を有するタンパク質をコードするＤＮＡ、（ｃ）（ａ）又は（ｂ）のＤＮＡの相補鎖。特定のアミノ酸配列を有するポリペプチド、又は前記配列の一部が、置換、付加或いは欠失したアミノ酸配列、若しくは前記配列のアミノ酸と８５％以上の同一性を有する、アミノ酸配列、で核酸のグアニン残基のＡＤＰリポシル化活性を有するポリペプチドを有する遺伝子。【選択図】図１
