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DERIVADOS DE ISOXAZOLIDINA
- 专利权人:
- CHIESI FARMACEUTICI S.P.A.
- 发明人:
- GHIDINI, ELEONORA
- 申请号：
- PE0002982015
- 公开号：
- PE06752015A1
- 申请日:
- 2013.08.23
- 申请国别(地区):
- PE
- 年份:
- 2015
- 代理人:
- 摘要：
- Referring to a isoxazolidina derivative Compound of formula (i).Preferred compounds are: 2 - [(4aS, 4bR, 5S, 6aS, 6BR, 9aS, 10aS, 10bS, 12S) - 8 - (4-chloro phenyl) - 4b, 12 - difluoro - 5 - hydroxy - 4a, 6a - dimethyl - 2 - oxo - 2,4a, 4b, 5,6,6a, 8,9,9a 10,10a, 10B, 11,12 -, oxa - tetradecahidro - 7 - 8 - aza - pentalen [2,1-a] fenantren - 6B - yl] - 2 - oxo - etilester isobutyric acid 2 - [(4aS, 4bR, 5S, 6aS, 6BR, 9aS, 10aS , 10bS, 12S) - 8 - (4-chloro phenyl) - 4b, 12 - difluoro - 5 - hydroxy - 4a, 6a - dimethyl - 2 - oxo - 2,4a, 4b, 5,6,6a, 8,9,9a, 10,10a, 10B, 11,12 - tetradecahidro - 7 - 8 - aza oxa - pentalen [2,1-a] fenantren - 6B - yl] - 2 - oxo propionic acid etilester among others. These compounds are anti-inflammatory and antiallergic of series of glucocorticosteroids. It also relates to a preparation Method, Pharmaceutical compositions and combinationsReferida a un compuesto derivado de isoxazolidina de formula (I). Son compuestos preferidos: 2-[(4aS,4bR,5S,6aS,6bR,9aS,10aS,10bS,12S)-8-(4-cloro-fenil)-4b,12-difluoro-5-hidroxi-4a,6a-dimetil-2-oxo-2,4a,4b,5,6,6a,8,9,9a,10,10a,10b,11,12-tetradecahidro-7-oxa-8-aza-pentalen[2,1-a]fenantren-6b-il]-2-oxo-etilester de acido isobutirico 2-[(4aS,4bR,5S,6aS,6bR,9aS,10aS,10bS,12S)-8-(4-cloro-fenil)-4b,12-difluoro-5-hidroxi-4a,6a-dimetil-2-oxo-2,4a,4b,5,6,6a,8,9,9a,10,10a,10b,11,12-tetradecahidro-7-oxa-8-aza-pentalen[2,1-a]fenantren-6b-il]-2-oxo-etilester de acido propionico entre otros. Dichos compuestos son anti-inflamatorios y antialergicos de la serie de los glucocorticosteroides. Tambien esta referida a un metodo de preparacion, composiciones y combinaciones farmaceuticas
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
