The present invention relates to novel cpd, especially according to the new pyridine ketone derivatives of chemical formula (I), wherein all groups such as in the application and claim definition.Compound according to the present invention is the positive allosteric modulators of metabotropic receptor-hypotype 2 (" mGluR2 "), and it can be used for treating or nerve and mental disorder that prevention is relevant with the L-glutamic acid dysfunction and the disease that wherein relates to the mGluR2 hypotype of metabotropic receptor.Especially, such disease is the central nervous system disorder that is selected from the group of anxiety disorder, schizophrenia, migraine, depression and epilepsy.The invention still further relates to pharmaceutical composition and such compound and the method for compositions of preparation, and such compound is in prevention with treat application in such disease that relates to mGluR2.
