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ПРИМЕНЕНИЕ ТЕНЕЙ БАКТЕРИЙ ДЛЯ ОПОСРЕДОВАННОЙ СТИМУЛЯЦИИ ВРОЖДЕННОГО ИММУНИТЕТА
专利权人:
ЛЮБИТЦ Вернер Проф. Др. (AT)
发明人:
ЛЮБИТЦ Вернер Проф. Др. (AT)
申请号:
RU2013109938/10
公开号:
RU2013109938A
申请日:
2011.08.05
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Shadow bacteria for use to stimulate an innate immune response, characterized in that the shadows of bacteria obtained from a strain E.coli.2. Shadows of bacteria according to claim 1, characterized in that the surface of the bacteria does not contain shadows flagellina.3 monomers. Shadows of bacteria according to claim 1, characterized in that the surface of the bacteria does not contain flagellin.4 shadows. Shadows of bacteria according to claim 1, wherein the innate immune response is stimulated by the induction of expression and / or release of at least one modulator of the innate immune otveta.5. Shadows of bacteria according to claim 4, wherein the expression and / or release of a modulator of innate immunity is induced in epithelial kletkah.6. Shadows of bacteria according to claim 5, wherein the epithelial cells are keratinotsitami.7. Shadows of bacteria according to claim 1, characterized in that the at least one modulator of innate immunity is selected from the group consisting of antimicrobial protection molecules, proinflammatory cytokines, reactive nitrogen species (RNS) and reactive oxygen species (ROS) .8. Shadows of bacteria according to claim 1, characterized in that the enhanced expression of at least one antimicrobial zaschity.9 molecule. Shadows of bacteria according to claim 8, characterized in that at least one antimicrobial protection molecule selected from the group consisting of psoriasin and β-defensin 2 (hBD2 -) 10.. Shadows of bacteria according to claim 1, characterized in that the enhanced expression and / or release of at least one proinflammatory tsitokina.11. Shadows of bacteria according to claim 10, characterized in that the at least one pro-inflammatory cytokine is selected from the group consisting of interleukin-6 (IL-6) and interleukin-8 (IL-8) .12. Shadows of bacteria according to claim 1 of1. Тени бактерий для применения с целью стимулировать врожденный иммунный ответ, отличающиеся тем, что тени бактерий получают из штамма
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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