Virginia Commonwealth University;George Mason University
发明人:
Jasmohan Bajaj,Patrick M. Gillevet
申请号：
US16339192
公开号：
US20190224252A1
申请日:
2017.10.05
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are compositions and methods for diagnosing fungal dysbiosis in the gut of a subject with cirrhosis that involves assaying a sample from the subject for bacterial taxa. These compositions and methods are based on the discovery that there is significant correlation between fungal and bacterial diversity in gut microbiota of cirrhotic patients. Therefore, disclosed herein is a method for treating a subject with liver cirrhosis that involves assaying a gut sample from the subject for bacterial taxa to generate a bacterial profile, comparing the bacterial profile to control profiles to predict fungal dysbiosis； and treating the subject for fungal dysbiosis.
