Doses containing pregnane glycosides alone, and in combination with several other compounds for treatment of disorders/conditions such as obesity, low BMR, hyperglycaemia, hypertension, hypercholesterolemia, Type (2) diabetes, migraine, osteo-arthritis and joint degradation/inflammation, clinical depression, menopausal syndrome, ageing syndrome, circulation syndrome, capillary degeneration, reduced cognitive and memory function, hearing loss, sexual dysfunction and others are disclosed. Doses are also provided for the regulation/improvement of various physiological parameters/conditions/functions associated with said disorders and others such as skin condition, joint mobility, mood, memory function and recall, lean body mass, stamina, libido and others. The preferred glycoside is a caralluma plant extract containing a synergical mixture of the pregnane glycosides, caratubersides and boucerosides containing 90-95% of the former. Combinations thereof with the extracts of Green tea, Fenugreek, Ashwagandha, Shilajith, Commiphora Mukul, Garcinia, Hibiscus Subdarifa, Coccinia, Bittergourd, Cinnamon, Liquorice, Red clover, Hops flowers, Pomegranate and with Glucosamine, Zinc monomethionine, Citrus bioflavonoids, Rutin, Bamboo silica, Shilajith, Saponin glycosides and the biders of caralluma, and selenium are disclosed.
