The invention provides a process, especially for the efficient reuse of human bone material, the process comprising (i) screening a bone part on the suitability for reuse in a human body, (ii) packaging the bone part, (iii) subjecting the bone part to a high pressure process, wherein the bone part enclosed by a package is subjected to a pressure selected from the range of 300-1000 MPa for a period of time selected from the range of 1-60 minutes, wherein the package comprises a closed polymeric package containing the bone part and an aqueous liquid, and (iv) optionally further packaging the thus obtained high pressure process processed bone part, wherein the bone part has one or more dimensions selected from the range of 1-65 cm.
