Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification

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专利权人:

Jean-Louis Maurel

发明人:

Jean-Louis Maurel,Richard Pena,Jean-Paul Ribet

申请号：

US12524898

公开号：

US08343991B2

申请日:

2008.02.13

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to anhydrous crystalline vinflunine salts obtained with 1 or 2 equivalents of a pharmaceutically acceptable mineral or organic acid [Acid] 1 or 2 in which [Acid] represents hydrobromic, sulfuric, lactic and fumaric acids for the group of water-soluble crystalline salts, and para-toluene sulfonic, benzoic, mandelic and para-hydroxy benzoic acids for the group of relatively insoluble crystalline salts.

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