The present invention generally relates to methods for removing plaque from a vessel. The method can involve obtaining a first image of a blood vessel using a first imaging modality, obtaining a second image of the blood vessel using a second imaging modality, and coregistering the first and second images, thereby generating a coregistered data set. The method can further involve inserting an atherectomy catheter into the blood vessel and removing plaque from the vessel with the atherectomy catheter based on plaque identified in the coregistered set of data.
