THE GOVERNMENT OF THE UNITED STATES OF AMERICA; REPRESENTED BY THE SECRE TARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
NEVILLE, DAVID M.,HU, HUAIZHONG,KNECHTLE, STUART J.,MA, SHENGLIN,THOMAS, JUDITH,THOMPSON, JERRY T.
申请号：
CA2218166
公开号：
CA2218166C
申请日:
1996.04.12
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Provided is a method of treating an immune system disorder not involving T-cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway, or derivatives thereof under conditions such that the disorder is treated. Thus, the present method can treat graft-versus-host disease. Also provided is a method of inhibiting a rejection response by inducing immune tolerance in a recipient to a foreign mammalian donor tissue or cells, comprising the steps of: a) exposing the recipient to an immunotoxin so as to reduce the recipients peripheral blood T-cell lymphocyte population by at least 80 %, wherein the immunotoxin is anti-CD3 antibody linked to a diphtheria protein toxin, wherein the protein has a binding site mutation and b) transplanting the donor cells into the recipient, whereby a rejection response by the recipient to the donor organ cell is inhibited, and the host is tolerized to the donor cell.
