7-[3,5-DIHYDROXY-2-(3-HYDROXY-5-PHENYL-PENT-1-ENYL)-CYCLOPENTYL]-N-ETHYL-HEPT-5-ENAMIDE (BIMATOPROST) IN CRYSTALLINE FORM II, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF
The present invention provides a new crystalline form of bimatoprost, designated as crystalline form II. This new crystalline form is the most stable form known to date of bimatoprost. Moreover, it has been found that bimatoprost crystalline form II is readily prepared from crystalline form I.Linvention concerne une nouvelle forme cristalline de bimatoprost, appelée forme cristalline II. Cette nouvelle forme cristalline est la forme la plus stable de bimatoprost connue à ce jour. De plus, il a été découvert que la forme cristalline II de bimatoprost est élaborée facilement à partir de la forme cristalline I.