A peritoneal-based ("bloodless") artificial kidney processesperitoneal fluid without need for additional fluids ("waterless").Fluid is separated into a protein-rich stream and a protein-free stream. Theprotein-rich stream is regenerated using a sorbent assembly, and its proteincomposition can be modified by removal of selected protein(s) ("dialysate-pheresis").It is then reconstituted with additives and returned into the peritoneal cavity,thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration.The protein-free stream is used to produce free water, and an alkaline or acidfluid for optimization of the composition of the regenerated stream. The unusedprotein-free stream can be used to "reverse flush" the separatorto maintain its patency and the excess discarded for fluid-balance regulation.Compared to prior art, immobilization of urease allows more protein rich fluidto be regenerated and re-circulated into the peritoneal cavity for toxin removaland allows practicable development of portable and wearable artificial kidneys.
