SCHOETTLE, Isabell,STOMMES, Judith,JANOCHA, Bernd,STILLGER, Ursula,BARTNIK, Eckart,JESKE, Volker,SAAS, Joachim
申请号：
EP16790269
公开号：
EP3350204A2
申请日:
2016.09.16
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.
