PROBLEM TO BE SOLVED: To provide a composition that reduces the pain and/or inflammation caused by oral disease comprising oral injury, stomatitis, periodontitis, tooth pain, pain after tooth extraction, or pain after oral surgical procedure, a method for preparing the composition, and a therapeutic method using the composition.SOLUTION: This invention provides a topical oral composition comprising ibuprofen ((2RS)-2(4-(2-methylpropyl)phenylpropanoic acid) or pharmacologically acceptable salt thereof and at least one carrier acceptable for an oral cavity, wherein the composition is in the form of aqueous solution, gel, or patch, and provides a method for preparing the composition, and a therapeutic method using the composition.COPYRIGHT: (C)2016,JPO&INPIT【課題】口内外傷、口内炎、歯周病、歯痛、抜歯後の疼痛、又は口腔外科手術後の疼痛を含む口腔内疾患に基因する疼痛及び/又は炎症を軽減する組成物、及びその組成物の調整方法、及びその組成物を用いた治療方法の提供。【解決手段】イブプロフェン((2RS)-2(4-(2-メチルプロピル)フェニルプロパン酸)又はその薬学的に許容される塩と少なくとも1つの口腔に許容可能な担体を含有する水溶液、ジェル状、又はパッチ状である局所口腔用組成物およびその組成物の調整方法、およびその組成物を用いた治療方法。【選択図】なし
