프레인 에디 진 에드가드,윌렘스 마크,텐 홀테 피터,파파니코스 알렉산드라,엠브레흐츠 베르너 콘스탄트 조안,스토르크 피에르 헨리,폰셀레트 버지니 소피
申请号：
KR1020077013133
公开号：
KR1013204310000B1
申请日:
2005.12.08
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
This invention relates to compounds of formula (I), their N- oxide forms, pharmaceutically acceptable relates to the addition salts and stereochemical isomers:wherein, Z represents a NH Y is -C 3 - 9 alkyl-, -C1-5 -NR13-C1-5 -, -C 1 -5 alkyl, -NR 14 -CO-C 1 - 5 alkyl-, -C1-2 -NR21-CH2-CO-NH-C1-3 - Or -C 1 - 2 alkyl, -NR 23 -CO-CR 16 R 17 represents the -NH- X 1 is O or -OC 1 - 2 alkyl-represents X 2 is a direct bond, -C 1 - 2 alkyl, -CO-C 1 -2 alkyl- or NR 12 -C 1 - 2 alkyl-represents R 1 is a hydrogen or halo R 2 represents a halo, acetylene or Het 1 R 3 is a hydrogen or cyano R 4 is Ar 4 -C 1-4 alkyloxy -, C 1 - 4 alkyloxymethyl - or Het 2 , NR 7 R 8 , hydroxy and C 1 - 4 alkyloxy -C 1 - 4 alkyloxy - C is selected if possible which one or two or more substituents substituted with from 1 - 4 represents an alkyloxy R 7 is hydrogen or C 1 - 4 and represents alkyl R 8 is NR 25 R 26 or C 1 - 4 C is substituted with an alkyl sulfonyl 1 - represents the 4 alkyl R 12 is hydrogen or C 1 - 4 alkyl-represents R 13 is Ar 6 - sulfonyl, or phenyl optionally substituted C 1 - 4 denotes an alkyl-oxy-carbonyl R 16 and R 17 is hydrogen or C 1 - 4 represents an alkyl or Or R 16 and R 17 is taken together with the carbon atoms to which they are bonded C 3 - 6 , and form a cycloalkyl R 23 is C 1 - 4 and represents alkyl R 23 is R 16 and R 17 taken together with the carbon atoms to which they are bonded C 3 - 6 represents hydrogen in the case of forming a cycloalkyl R 25 , R 26 , R 27 and R 28 are each independently hydrogen or C 1 - 4 represents an alkyl carbonyl Het 1 denotes the 2-Look-1,3-dioxolanyl Het 2 denotes the piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl or 1,1-dioxo-thiomorpholinyl, where Het 2 a C 1 - 4 alkoxycarbonyl or NR 27 R 28 - C 1 - 4 is optionally substituted alkyl Ar 4 and Ar 5 repr
