Xiangming Guan,Chandrahar Dwivedi,Yinghong Li,Yang Yang,John H. Lee,Wilson Keith Miskimins
申请号：
US14699946
公开号：
US09556113B2
申请日:
2015.04.29
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation therapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways.
