Lanzhou Institute Of Chemical Physics Chinese Academy of Sciences
发明人:
申请号：
EP18173178.7
公开号：
EP3403651B1
申请日:
2018.05.18
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Present invention discloses a chemically structural derivative of isocorydine (see formula I), which is prepared by amidation condensation reaction between an amino group of NICD and a carbonyl group of an aryl isocyanate, a carboxylic acid, or an acid chloride, or symmetrical amidation condensation reaction between an NICD and an aromatic amino group by solid phosgene. This type of compounds has a certain anti-cancer activity in vivo and in vitro, and may be used as drugs for preventing and treating cancer. wherein in the chemical structure of formula I: R 1 = X = N, C, C=C； n 1 = 0, 1 R 2 = H, R 1 Y = C,N R 3 = H, Cl, Br, F, CF 3 , OCH 3 , CH 3 , Z = H, Cl, F, N； n 2 = 0, 1 R 4 = NH 2 , CH 2 NH 2 , NHCO(CH 2 ) n3 CH 3 , CH 2 NHCO(CH 2 ) n3 CH 3 , n 3 = 0, 1,2
