Thomas E. Jenkins,Craig O. Husfeld,Julie D. Seroogy,Jonathan W. Wray
申请号：
US13686710
公开号：
US20130210700A1
申请日:
2012.11.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenol-modified opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the phenol-modified opioid prodrug so as to modify enzymatic cleavage of the phenol-modified opioid prodrug.
