van Loevezijn, Arnold,Iwema Bakker, Wouter I.,Stoit, Axel,Rensink, Agatha A.M.,Venhorst, Jennifer,van der Neut, Martina A.W.,de Haan, Martin,Kruse, Cornelis G.
申请号：
ES13161112
公开号：
ES2577867T3
申请日:
2009.03.17
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (1): ** Formula ** or a tautomer, stereoisomer, N-oxide or a pharmacologically acceptable salt of any of the foregoing, where: - R1 is selected from hydrogen or a C1-4 alkyl group, optionally substituted with one or more halogen atoms or a hydroxyl group, - R2 and R3 are independently selected from hydrogen, a hydroxyl group or a C1-4 alkyl group, optionally substituted with one or more substituents Q, independently selected from : halogen, C1-4 alkyl, C1-4 alkenyl, C1-4 alkynyl, CF3, NH2, C1-4alkyl, N [C1-4 alkyl] 2, OH,>； = O, O-alkyl of C1-4, or OCF3, or, R1 and R2, together with the carbon atoms labeled 'a' and 'b' form a C5-8 cycloalkyl ring, optionally substituted with one or more halogen atoms, a hydroxyl group or a C1-4 alkyl group, or R2 and R3, together with the carbon atom labeled 'b', forms a C3-8 cycloalkyl ring or an ani The C4-8 heterocycloalkyl, optionally substituted with one or more substituents Q as defined above, - R4 and R5 are independently selected from hydrogen or a C1-4 alkyl group, optionally substituted with one or more substituents Q , as defined above, or R4 and R5 are independently selected from an aromatic or heteroaromatic, monocyclic or bicyclic fused group, optionally substituted with one or more substituents Q, as defined above, with the proviso that Q cannot be>； = O (keto) in the aromatic rings, or R3 and R4, together with the carbon atoms labeled 'b' and 'c' form a C3-8 cycloalkyl or C5-8 heterocycloalkyl ring, optionally substituted with one or more substituents Q as defined above, - R6 and R7 are independently selected from hydrogen or a C1-4 alkyl group, optionally substituted with one or more halogen atoms or a hydroxyl group or a C1-3-C1-3 amino-alkyl group, or R6 and R7 are independently selected from a fused, aromatic or hetero-aromatic monocyclic or bicyclic group, optionally substituted with one or more substituents Q, such as defined above, or R6 and R7 are independently a C5-8 cycloalkyl grou
