To methods and compositions for the improvement of prevention and treatment of symptoms is described signs and / or associated with the skin disorder or inflammatory skin disorders. The method comprises topical application to the skin of the combination of non-steroidal anti-inflammatory drugs such as diclofenac and a therapeutically effective amount of α2 adrenergic receptor agonists, such as brimonidine therapeutically effective amount.炎症性皮膚障害又はその皮膚障害に伴う徴候及び/若しくは症状の治療及び予防の改善のための方法及び組成物が記載される。この方法は、治療有効量のブリモニジンなどのα2アドレナリン受容体アゴニスト、及び治療有効量のジクロフェナクなどの非ステロイド性抗炎症薬の組み合わせの皮膚への局所適用を含む。
