patent summary: "2,7-diaza-spiro [4.5] dec-7-yl 1-malate salt derivatives and crystalline forms thereof as ghrelin receptor agonists". the invention relates to 2-amino-n - [(r) -1-benzyloxymethyl-2 - ((4s, 5r) -2-methyl-1-oxo-4-phenyl-2,7-1-malate salt -diaza-spiro [4.5] dec-7-yl) -2-oxo-ethyl] -2-methyl-propionamide, 2-amino-n - ((2r) -3- (benzyloxy) -1-malate salt - (2-methyl-1-oxo-4-p-tolyl-2,7-diazaspiro [4.5] decan-7-yl) -1-oxopropan-2-yl) -2-methylpropanamide and 2-malate salt -amino-n - ((r) -1-benzyloxy-methyl-2 - [(45,5r) -4-fluorophenyl) -2-methyl-1-oxo-2,7-diazaspiro [4,5] decan-7-yl) -2-oxoethyl} 2-methylpropanamide and to crystalline forms thereof； pharmaceutical compositions comprising such compounds and compounds for the treatment of a ghrelin receptor-mediated disorder or disease.resumo patente de invenção: "derivados de sal l-malato de 2,7-diaza-espiro[4.5]dec-7-il e formas cristalinas dos mesmos como agonistas do receptor de grelina". a invenção refere-se ao sal l-malato de 2-amino-n-[(r)-1-benzilóximetil-2-((4s,5r)-2-metil-1-oxo-4-fenil-2,7-diaza-espiro[4.5]dec-7-il)-2-oxo-etil]-2-metil-propionamida, sal l-malato de 2-amino-n-((2r)-3-(benzilóxi)-1-(2-metil-1-oxo-4-p-tolil-2,7-diazaespiro[4.5]decan-7-il)-1-oxopropan-2-il)-2-metilpropanamida e sal l-malato de 2-amino-n-((r)-1-benzilóxi-metil-2-[(45,5r)-4-fluor-fenil)-2-metil-1-oxo-2,7-diazaespiro[4,5]decan-7-il)-2-oxoetil}2-metilpropanamida e a formas cristalinas dos mesmos； composições farmacêuticas compreendendo tais compostos e tais compostos para o tratamento de um transtorno ou uma doença mediada pelo receptor de grelina.
