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用於治療犬癌症的嵌合AAV-抗VEGF
专利权人:
The Trustees of The University of Pennsylvania;賓夕法尼亞大學
发明人:
HINDERER, Christian,WILSON, James, M.,WILSON, Matthew,J.M.威爾遜,WILSON, Matthew,M.威爾遜
申请号:
HK18116280
公开号:
HK1257490A1
申请日:
2018.12.19
申请国别(地区):
HK
年份:
2019
代理人:
摘要:
Compositions and methods are provided for treating hemangiosarcoma in a subject. A recombinant AAV comprising a capsid and a vector genome comprising a nucleic acid expression cassette is provided. The expression cassette includes sequences encoding a promoter, a first signal peptide operably linked to an anti-VEGF antibody heavy chain immunoglobulin, a linker sequence, and a second signal peptide operably linked to an anti-VEGF light chain immunoglobulin, wherein said expression cassette co-expresses the immunoglobulin chains in a host cell under conditions which permit the chains to assemble into a functional anti-VEGF antibody. In one embodiment, the anti-VEGF antibody is a chimeric antibody.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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