The invention relates to in vivo dosimetry techniques and can be used for comparison of dose measured in reference point and dose calculated at the same place with computerized treatment planning system. The suggested method takes into consideration dose difference and distance-to-agreement between measured and calculated points and uses a region of measurements (ROM) contoured as an organ at risk so that dose differences inside the ROM and acceptance interval are defined with the dose volume histogram of the ROM. The method can be used for evaluation of influence of ROM homogeneity and dosimeter movement on the difference between calculated and measured doses.