The instant invention provides materials and methods for producing immunologically active antigens derived from members of the Picornaviridae virus family. The picornavirus antigens of the invention may be in a form for use as a vaccine administered to a subject in a therapeutic treatment or for the prevention of a picornavirus infection. The picornavirus antigens of the invention may be in the form of an immunogenic composition for use in vaccines which are administered for the prevention of an Enterovirus infection. The instant invention further encompasses immunogenic compositions comprising Human enterovirus A, Human enterovirus B, Human enterovirus C, Human enterovirus D antigens and their use in vaccines for the prevention of an Enterovirus infection.本發明提供用於產製源自小核糖核酸病毒科(Picornaviridae)成員之免疫活性抗原類之材料及方法。本發明之小核糖核酸病毒抗原類可呈現作為疫苗之形式,藉以投予至個體以治療性治療或預防小核糖核酸病毒感染。本發明之小核糖核酸病毒抗原類可呈現免疫原性組成物之形式,藉以用於經投予以預防腸病毒感染之疫苗。本發明另包含免疫原性組成物,其包含人腸病毒A型、人腸病毒B型、人腸病毒C型、人腸病毒D型抗原類,及彼等作為疫苗以預防腸病毒感染之用途。
