DANIEL H. MAES,DONALD F. COLLINS,EDWARD PELLE,JAMES TIMOTHY MCCARTHY,KERRI GOLDGRABEN,LENNEY SLUTSKY,NADINE A. PERNODET,THOMAS MAMMONE
申请号：
BRPI1015932
公开号：
BRPI1015932A2
申请日:
2010.06.09
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.
