Example biosensor devices having wake-up batteries and associated methods are disclosed. One example device includes a biosensor that has a first electrode for insertion into a subcutaneous layer beneath a patient’s skin, and a second electrode coupled to the first electrode for insertion into the subcutaneous layer, and a first battery to apply a voltage across the first and second electrodes, the first battery at least partially electrically decoupled from the electrodes. The device also includes a second battery having an anode material coupled to the first electrode for insertion into the subcutaneous layer, and a portion of the second electrode. The second battery is activatable upon immersion in an electrolytic fluid. The device also includes a wake-up circuit to receive a signal from the second battery and, in response, to electrically couple the first battery to the first and second electrodes to activate the biosensor.本發明揭示具有喚醒電池之例示性生物感測器裝置及相關聯方法。一個例示性裝置包含具有用於插入至患者之皮膚下方之皮下層中之第一電極及耦合至用於插入至該皮下層中之該第一電極之第二電極,及跨該等第一及第二電極施加電壓之第一電池,該第一電池至少部分與該等電極電解耦合。該裝置亦包含第二電池,其具有耦合至用於插入至該皮下層中之該第一電極之陽極材料,及該第二電極之部分。該第二電池可在浸沒於電解流體中之後啟動。該裝置亦包含喚醒電路以從該第二電池接收信號,且作為回應,將該第一電池電耦合至該等第一及第二電極以啟動該生物感測器。200‧‧‧生物感測器210‧‧‧感測器元件212‧‧‧電極220‧‧‧電池222‧‧‧導電接觸件224‧‧‧導電接觸件230‧‧‧第二電池232‧‧‧陽極材料240‧‧‧喚醒電路250‧‧‧發送器252‧‧‧天線