Edward Conway,Jing Zhao Cui,Jonathan Foley,Michael Krisinger,Joanne Matsubara,Linnette Ocariza,Jovian Wat
申请号：
US14536520
公开号：
US09408871B2
申请日:
2014.11.07
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides methods for inhibiting complement activation and uses thereof. More specifically, the present invention provides methods for inhibiting complement activation using inorganic polyphosphates of at least 10 phosphate units. The polyphosphates inhibit complement activation by one or more of: binding to the C6 complement protein, C1-esterase inhibitor (C1-inh), factor H or factor B enhancing the activity of C1-inh interfering with C1s-mediated cleavage of C2 destabilizing the C5b-6 complement protein complex interfering with C5b,6 interaction with C7 interfering with binding of C5b-7 to a cell membrane interfering with integration of C5b-7 into a cell membrane interfering with binding of C5b-8 to a cell membrane interfering with integration of C5b-8 into a cell membrane destabilizing the membrane attack complex (MAC) or reducing the amount of C5b-9 deposited on a cell surface.
