HETEROARYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR PRODUCING THE SAME, AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING PI3-KINASE RELATED DISEASES COMPRISING THE SAME AS THE ACTIVE INGREDIENT
The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a method for producing the same, and a pharmaceutical composition for preventing or treating PI3 kinase related diseases comprising the same as an active ingredient. The heteroaryl derivative according to the present invention is excellent in the selective inhibitory effect on PI3 kinase, and thus, hematologic cancer, ovarian cancer, cervical cancer, breast cancer, colon cancer, liver cancer, gastric cancer, pancreatic cancer, colon cancer, peritoneal Cancers such as metastatic cancer, skin cancer, bladder cancer, prostate cancer, lung cancer, osteosarcoma, fibrotic tumor, brain tumor, etc., rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, thyroid function Autoimmune disease, myasthenia gravis, Crohn's disease, ankylosing spondylitis, psoriasis, autoimmune disease such as autoimmune anemia, Sjogren's syndrome etc., chronic obstructive pulmonary disease (COPD), rhinitis, asthma, chronic bronchitis, To prevent or treat PI3 kinase related diseases such as chronic pulmonary inflammatory diseases, silicosis, pulmonary sarcoidosis, pleuritis, alveolitis, vasculitis, emphysema, pneumonia, respiratory diseases such as pneumonia, bronchiectasis etc. To be useful Kill. 【Selection chart】 None本発明は、ヘテロアリール誘導体またはその薬学的に許容可能な塩、その製造方法、及びそれを有効成分として含むPI3キナーゼ関連疾患の予防または治療用薬学的組成物に関する。本発明に係るヘテロアリール誘導体は、PI3キナーゼに対して選択的に抑制する効果に優れるので、血液癌、卵巣癌、子宮頸部癌、乳癌、大腸癌、肝癌、胃癌、膵癌、結腸癌、腹膜転移癌、皮膚癌、膀胱癌、前立腺癌、肺癌、骨肉腫、線維性腫瘍、脳腫瘍などのような癌、リューマチ性関節炎、全身性紅斑性狼瘡、多発性硬化症、第1型糖尿病、甲状腺機能亢進症、筋無力症、クローン病、強直性脊椎炎、乾癬、自己免疫性悪性貧血、シェーグレン症候群などのような自己免疫疾患、慢性閉塞性肺疾患（COPD）、鼻炎、喘息、慢性気管支炎、慢性肺炎症性疾患、珪肺症、肺型サルコイドーシス、胸膜炎、肺胞炎、血管炎、気腫、肺炎、気管支拡張症などのような呼吸器疾患などのPI3キナーゼ関連疾患を予防または治療するのに有用に用いることができる。【選択図】なし
