The invention concerns a modified vaccinia virus Ankara (MVA) expressing at least 3 external influenza virus antigens and at least 3 internal influenza virus antigens, wherein the genes encoding the antigens are inserted into at least two MVA insertion sites. The invention, thus, concerns a recombinant MVA virus encoding multiple external and/or internal influenza virus antigens, preferably from multiple influenza virus strains. The invention further concerns the use of said recombinant MVA in preparing a medicament and vaccine for influenza virus. Further encompassed by the present invention are methods, composition and kits.
