The purpose of the present invention is to provide a liquid supply device and biological cleaning device that, by supplying a sterile liquid including low-flow, low-pressure microbubbles, can dramatically increase cleaning effects and clean quickly and neatly without damaging a biological tissue. A liquid cleaning device (3), having a supply flow path (2) for supplying a liquid including microbubbles to a cleaning instrument (1) for cleaning an organism and to a cleaning target such as a medical instrument, is characterized by being provided with a tube pump (5) for delivering the liquid to the supply flow path (2) and a microbubble generator (B) that is provided midway on the supply flow path (2) and is for causing microbubbles to be generated in the liquid.