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Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby
专利权人:
Mali Kadosh;Dorit Marco;Ilan Zalit;Yonit Messer-Triger;Fanny Leska
发明人:
Ilan Zalit,Fanny Leska,Mali Kadosh,Dorit Marco,Yonit Messer-Triger
申请号:
US10986494
公开号:
US08367105B2
申请日:
2004.11.10
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
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