A method for treating a neuroendocrine tumor, particularly pancreatic neuroendocrine tumor, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, alone or in combination with at least one therapeutic agent, wherein said neuroendocrine tumor is resistant or refractory to treatment with at least one mTOR inhibitor； uses of said compounds for the preparation of a medicament for use in the treatment of a neuroendocrine tumor resistant or refractory to treatment with at least one mTOR inhibitor, uses of said compound for treating said disease； and related pharmaceutical compositions and pharmaceutical package thereof.本發明係關於治療神經內分泌腫瘤(尤其是胰臟神經內分泌腫瘤)之方法，其包含向有需要之個體單獨或與至少一種治療劑組合投與治療有效量之式(I)化合物或其醫藥上可接受之鹽，其中該神經內分泌腫瘤對利用至少一種mTOR抑制劑之治療具有抗性或難治性；該等化合物用於製備用以治療對利用至少一種mTOR抑制劑之治療具有抗性或難治性之神經內分泌腫瘤之藥劑之用途；該化合物用於治療該疾病之用途；以及其相關醫藥組合物及醫藥包裝。
