Edward A. Dennis,George Kokotos,Violetta Constantinou-Kokotou,Samuel David
申请号：
US12994136
公开号：
US08759392B2
申请日:
2009.07.21
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods and compounds useful for inhibiting a phoshpolipase A2 are provided, the methods comprising contacting the phoshpolipase A2 with a compound having the structure A, or pharmaceutically acceptable salts thereof: wherein R1 is H, F, NH2, or COOH R2 is, H, linear saturated or unsaturated alkyl, alkenyl, or alkynyl each of R3 and R4 is independently H, linear saturated or unsaturated alkyl, alkenyl, alkynyl, phenyl, or substituted phenyl R5 is H, (C1-C6) alkyl such as methyl or ethyl X is aryl or substituted aryl, such as phenyl or a substituted phenyl and Y is O or S.
