4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one (Ropinirole) a New Inhibitor of Jack bean Urease Enzyme: An Example of Drug Repurposing

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专利权人:

Jalaluddin Azam Jalal Khan

发明人:

Jalaluddin Azam Jalal Khan,Muhammad Iqbal Choudhary,Maryam Abdu Abdullah AL-Ghamdi,Etimad Huwait,Atia-tul Wahab,Sumaira Javaid

申请号：

US15061280

公开号：

US20170252323A1

申请日:

2016.03.04

申请国别(地区):

US

年份:

2017

代理人:

摘要：

This invention provides that Ropinirole (4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one) possess potent urease inhibitory potential (in vitro) with 97.3% inhibition and IC50=11.7+0.46 μM, when compared to the standard inhibitors i.e. acetohydroxamic acid (IC50=41.5+1.50 μM), and thiourea (IC50=21.0+0.50 μM).

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