A medication delivery device (1) comprising a housing (3) having a proximal and a distal end, a medication receptacle (2) designed to be engaged with the distal end of the housing by engagement of first engagement means (5) with second engagement means (4) and a dosing mechanism. The dosing mechanism includes a piston rod (17) which is moveable in a distal direction for medication delivery and a drive device for moving the piston rod in the distal direction for medication delivery. The medication receptacle comprises an actuation means for bringing and holding a guiding means (11) in a guiding position in which the guiding means guides the piston rod for medication delivery. The first engagement means and the second engagement means are moveable into engagement by a movement of the medication receptacle which ends in a rotational movement without axial movement of the medication receptacle with respect to the housing, the actuation means thereby bringing the guiding means in the guiding position.
