The present disclosure a method and nutritional composition for improving the microbiome and metabolic profile of a pediatric subject, which includes administering to a pediatric subject a composition having up to about 7 g/100 kCal of a protein or protein equivalent source up to about 7 g/100 kCal of a fat or lipid source at least about 5 g/100 kCal of a carbohydrate at least about 0.05 mg/100 kCal of bacterial metabolites and either a probiotic or a prebiotic composition, or both.本發明揭示用於改善小兒個體的微生物群(microbiome)及代謝輪廓(profile)之方法及營養組成物,該方法包括投與小兒個體組成物,該組成物具有達至約7g/100kCal之蛋白質或蛋白質等效來源;達至約7g/100kCal之脂肪或脂質來源;至少約5g/100kCal之碳水化合物;至少約0.05mg/100kCal之細菌代謝物;及益生菌(probiotic)或益生素(prebiotic)組成物或該兩者。
