Methods and materials relating to a medicament preparation comprising a curcuminoid component, such as curcumin, and a polymer component having a backbone comprising polymethacrylate or methyl methacrylate provided as a curcuminoid-polymer complex, which enhances the solubility, stability and bioavailability of the curcumin component and are useful for the treatment of various inflammatory diseases and conditions when delivered to the gastro-intestinal tract, including sepsis, mucositis, gastritis, infections, inflammatory bowel disease and cancers of GIT. The curcumin-polymer complex inhibiting the activation of TLR receptors and thereby reduce the release of inflammatory cytokines, such that the curcumin-polymer complexes are more potent than free curcumin in antagonizing on the activation of TLR4.
