An apparatus for generating and collecting saliva samples containing enhanced cell concentrations includes a mouthpiece having a mouth contact portion and a flow channel which may include a tapered basin, a conduit in fluid communication with the flow channel, and one or more collectors couplable to the conduit. The mouth contact portion and basin may be textured to enhance cell removal. The mouth contact portion may include a plurality of internal and external channels disposed around the flow channel. Filters may be included between the flow channel and the collectors. A closure member is provided.
