The invention relates to methods for treating of tumor metastasis, methods for preventing, inhibiting, and predicting tumor recurrence and tumor metastasis, and methods of preventing cancer development for one at risk of developing cancer, for one diagnosed with a benign cancer, and/or for one diagnosed with malignant cancer. The invention also relates to methods of treating angiogenesis-dependent diseases and disorders. In addition, the invention provides: (1) a method for screening for tumor/cancer derived angiogenesis and metastasis factors； (2) a method for screening for compounds that inhibit angiogenesis and metastasis； (3) a method for screening for compounds that promote anti- angiogenesis and anti-metastasis activities； (4) a method for cancer prognosis evaluation； (5) a method for predicting the tissue specificity of a metastastic cancer； (6) a method for determining likelihood of metastasis； and (7) a method for cancer prognosis evaluation by the surveillance of metastasis development.
