The present invention relates to a pharmaceutical composition comprising: (i) a therapeutically effective amount of at least one antibiotic and (ii) a therapeutically effective amount of both an uridine and pyruvate compound. The formulation is prepared in a suitable dosage form for the delivery of antibiotics and the reduction of the known adverse side-effects of the antibiotics is achieved by the added uridine and pyruvate compounds when administered to a subject. The present invention neutralizes highly efficient these side-effects without interfering with the antibiotic effect of the drugs. By co-administration of antibiotics and uridine and pyruvate compounds, cells capability to generate energy and synthesize nucleic acids is being supported. Especially side-effects caused by antibiotics that interfere with the cellular and mitochondrial metabolism are effectively removed as secondary actions of the drugs. Also included are methods of reducing or preventing a failure of treatment for an antibiotic-treatable infection in a patient comprising administering the formulation in a suitable way of administration.Linvention concerne une composition pharmaceutique comprenant (i) une quantité suffisante dau moins un antibiotique associée à (ii) une quantité suffisante dun composé à base non seulement duridine mais aussi de pyruvate. Cette formulation est élaborée sous une forme posologique convenant à ladministration dantibiotiques, la réduction des effets secondaires connus des antibiotiques étant obtenue par adjonction, lors de ladministration au patient, de composés à base duridine et de pyruvate. Linvention neutralise puissamment ces effets secondaires sans interférer avec laction antibiotique des médicaments. Ladministration conjointe des antibiotiques et de ces composés à base duridine et de pyruvate aide les cellules dans leurs fonctions de production dénergie et de synthèse des acides nucléiques. Linvention permet ainsi de supprimer les effets secondaires imputa
