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Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders
- 专利权人:
- Pfizer Inc.
- 发明人:
- CABRAL, Shawn,FUTATSUGI, Kentaro,HEPWORTH, David,HUARD, Kim,KUNG, Daniel Wei-Shung,ORR, Suvi Tuula Marjukka,SONG, Kun
- 申请号：
- ES15710006
- 公开号：
- ES2674240T3
- 申请日:
- 2015.03.03
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- A compound of Formula (I) ** Formula ** in which D is N, CH, or C-F； R1 is (C1-C4) alkyl optionally substituted with one, two or three substituents each independently selected from fluoro and cycloalkyl (C3-C6)； R2 is fluoro or (C1-C4) alkyl； R3 is H, (C1-C4) alkyl, or (C3-C6) cycloalkyl； R4 is H, -C1-C4 alkyl, - (C1-C4 alkyl) p-C3-C6 cycloalkyl, - (C1-C4 alkyl) p-heterocyclyl (C3-C6), - ( ((C1-C4) alkyl) p-aryl, or - (((C1-C4) alkyl) p-heteroaryl in which R4 is optionally substituted with one, two, three, or four substituents selected from halo, cyano, oxo , aminyl, iminyl, -OH, -C1-C4 alkyl, -fluoroalkyl (C1-C4), -alkoxy (C1-C4), -cycloalkoxy (C3-C6), -fluoroalkoxy (C1-C4), - ( (C1-C4) alkyl) q-COOH, - ((C1-C4) alkyl) q-cycloalkyl- (C3-C6) - COOH, - ((C1-C4) alkyl) q-heterocyclyl (C3-C6) - COOH, - (C1-C4 alkyl) q-aryl-COOH, - ((C1-C4) alkyl) q-heteroaryl-COOH, - O - (((C1-C4 alkyl)) q-COOH, -O - (((C1-C4) alkyl) q-aryl-COOH, -O - (((C1-C4) alkyl) q-heteroaryl-COOH, - ((C1-C4) alkyl) (C3-C6) cycloalkyl, - ((C1-C4) alkyl) q-heterocyclyl (C3-C6), - ((C1-C4) alkyl) q-aryl, - ((C1-C4) alkyl) q-heteroaryl, - C (O) - (C1-C4) alkyl, -C (O) -alkoxy (C1-C4), -C (O) -cycloalkyl (C3-C6), -C (O) -heterocyclyl (C3-C6), -C (O ) - NR6R7, -C (O) - ((C1-C4) alkyl) q-aryl, -C (O) - (a (C1-C4) alkyl) q-heteroaryl, -NR6R7, -NR6-C (O) -R7, - ((C1-C4) alkyl) q-O20 aryl, - ((C1-C4) alkyl) qO-heteroaryl , -S (O) 2-R7, and -S (O) 2-NR6R7； or R3 and R4 can be joined to form a fully saturated or partially saturated 4 to 10 membered ring system optionally substituted with one, two, three, or four substituents selected from halo, cyano, -OH, - (C1-C4) alkyl , -fluoroalkyl (C1-C4), -alkoxy (C1-C4), -cycloalkoxy (C3-C6), -fluoroalkoxy (C1-C4), - (alkyl (C1-C4)) q- COOH, - (alkyl ( C1-C4)) q-cycloalkyl (C3-C6) -COOH, - ((C1-C4) alkyl) q-heterocyclyl (C3-C6) -COOH, - ((C1-C4) alkyl) q-aryl- COOH , - ((C1-C4) alkyl) q-heteroaryl-COOH, -O - (((C1-C4) alkyl) q-COOH, -O - (((C1-C4) alkyl) q-aryl-COOH,
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
