FORME ANHYDRE CRISTALLINE DU CABAZITAXEL, SON PROCEDE DE PREPARATION ET SES COMPOSITIONS PHARMACEUTIQUES

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专利权人:

INDENA S.P.A.

发明人:

CABRI, WALTER,CICERI, DANIELE,DOMENIGHINI, LUCA,GAMBINI, ANDREA,PETERLONGO, FEDERICO

申请号：

CA2928305

公开号：

CA2928305A1

申请日:

2014.10.09

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The present invention relates to a new anhydrous crystalline form of Cabazitaxel of formula (I), designated as form H. A further object of the present invention is a processes for the preparation of the above mentioned form H by recrystallization of Cabazitaxel from a mixture of decanoyl- and octanoyl triglycerides or from glycerol trioctanoate. Form H of Cabazitaxel is useful for the preparation of Cabazitaxel, Cabazitaxel salts, and polymorphic forms thereof. It is also particularly useful as a medicament, especially for the treatment of cancers.

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