FURER, PATRICK BLASIUS,GILISSEN, RONALDUS ARNODUS HENDRIKA JOSEPH,HOUPIS, IOANNIS NICOLAOS,MEERPOEL, LIEVEN,PERERA, TIMOTHY PIETRO SUREN,PYE, PHILIP JAMES
申请号：
CA2968294
公开号：
CA2968294A1
申请日:
2015.12.03
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention is directed to a triazolopyridazine compound of formula (I), N-oxides, pharmaceutically acceptable salts and solvates thereof, wherein D represents deuterium, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
