Targeting Intracellular Copper Ions for Inhibiting Angiogenesis Using Nanoparticles of Ternary Inorganic Metal Sulfide M1M2S4 (M1, independently, is Mg, Ca, Mn, Fe, or Zn； M2 = Mo or W) Compounds to Treat Metastatic Cancer
Songping D. HUANG,Gail C. FRAIZER,Vindya S. PERERA
申请号：
US14941081
公开号：
US20160220500A1
申请日:
2015.11.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This invention describes a new type of covalent-network ternary inorganic metal sulfide compounds M1M2S4 (M1, independently, is, Mg, Ca, Mn, Fe, or Zn； M2=Mo or W) and a process for preparing the biocompatible nanoparticles of such compounds. The nanoparticles are surface-modified with a capping agent and/or a biocompatible polymer and have the size from a few nanometers to several thousand nanometers. These nanoparticles are nontoxic and can be internalized by cells to deplete copper ions via a highly selective ion-exchange reaction between the intracellular copper ions and the divalent ion bound in the nanoparticles for the application of inhibiting angiogenesis in cancer and other diseases.
