Optionally substituted 3-(thio, sulfْnyl or sulfonyl)-7,8-dihydro-(1H or 2H)- imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one or a substituted 3-(thio, sulfinyl or sulfonyl)-7,8,9-trihydro— (1H or 2H)-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5اH)- one compounds or Compounds of Formula (I), processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them.